This application note demonstrate that the use of an inappropriate vial can cause analyte adsorption or degradation, potentially leading to out of specification (OOS) results also describes how the type of glass vial selected can impact sample stability, demonstrated for lactone-containing analytes.
This application note demonstrate that the use of an inappropriate vial can cause analyte adsorption or degradation, potentially leading to out of specification (OOS) results also describes how the type of glass vial selected can impact sample stability, demonstrated for lactone-containing analytes.
Sep 5, 2014 · 10.1016/j.chroma.2014.06.072 In the drug-discovery setting, the development of new peptide and protein-based biopharmaceuticals attracts increased attention from the pharmaceutical industry and consequently demands the development of high-throughput LC-MS methods.
Aug 20, 2020 · The analyte concentration and sample volume will also influence analyte recovery. Each surface has a finite number of active sites, therefore for the same vial a similar amount of analyte will be lost regardless of the sample and will cause the biggest problems for low volume and low concentration samples.
As previously reported, some types of vials can cause non-specific adsorption or degradation of pharmaceuticals. 1–5 The data shown here compares three types of vials for the analysis of two small molecule pharmaceuticals, drospirenone, and lovastatin. Solutions of these active pharmaceutical ingredients are shown to be stable when stored in
This application note demonstrate that the use of an inappropriate vial can cause analyte adsorption or degradation, potentially leading to out of specification (OOS) results also describes how the type of glass vial selected can impact sample stability, demonstrated for lactone-containing analytes.
1) The low-adsorption glass vials (LabTotal vials) inhibit the adsorption of basic compounds. 2) The low-adsorption PP vials (TORAST-H TM Bio vials) inhibit the adsorption of peptides. These low-adsorption vials are expected to help ensure the reliability of high-sensitivity analysis.
Apr 15, 2023 · Nonspecific adsorption of analytes is not reserved to metallic surfaces, as analytes may adsorb to the surfaces of filters, tubes, and pipette tips during sample preparation. Identifying the source of nonspecific interactions is paramount, as mitigation strategies may differ depending on what stage nonspecific losses are taking place.
Oct 17, 2018 · All solutions were prepared only once. Each solution was transferred into four different types of vials as listed in “Materials and Reagents”. For each vial type, 1.0 mL of a prepared solution was added into two separate vials using plastic disposable pipette. For each vial, three consecutive injections were made using the chromatographic
Oct 7, 2020 · In this study, we take a comprehensive approach to combat analyte adsorption by showing the significance of utilizing low-bind vials and adsorption competitors to greatly improve upon signal sensitivity at low concentrations of target molecules.
May 24, 2018 · An appropriate control strategy may comprise one or more elements of raw material, in-process and manufacturing controls. Additionally, understanding the role, if any, polysorbates play during stability will require knowledge of the criticality of the excipient, based upon its impact on CQAs due to variations in concentration and degradation level.