Jun 30, 2021 · UV-Vis spectroscopy is an analytical technique that measures the amount of discrete wavelengths of UV or visible light that are absorbed by or transmitted through a sample in comparison to a reference or blank sample. This property is influenced by the sample composition, potentially providing information on what is in the sample and at what
Feb 13, 2017 · As such, it’s critical to ensure that your analytical balances provide precise results. Here are 6 tips to help you get more accurate results from these instruments: 1. Pick the Right Environment. The accuracy of any weighing equipment can be affected by environmental factors and operating conditions, such as temperature, air pressure
Feb 17, 2021 · The solid form of a pharmaceutical has a tremendous impact on its materials properties, particularly solubility, dissolution rate, morphology, and tableting characteristics. Poor solubility is now one of the leading challenges in drug development and can cause the failure of promising new chemical entities, an issue exemplified by the often
May 27, 2020 · Understanding Extractable and Leachable Contamination Sources. Extractables are compounds present in packaging materials (and medical devices, such as pre-filled syringes) that can be forced to migrate out of the material under stressful conditions, for example exposure to strong solvents and high temperatures.
assay can have a critical effect on the accuracy, precision, and convenience of the final method, space limitations preclude us from addressing all of these areas in detail. Only steps 1 and 4 (sample collection and preliminary sample processing) will be briefly explained here. See References 1-4 for an explanation of steps 2, 3, and 5.
Jul 6, 2021 · age. Pre-analytical errors can induce systematic bias and imprecision, which may compromise research results, and are easyto avoidwith anadequatestudy design. Academic clinicians and investigators must be aware of the basic considerations for biospecimen management and essential pre-analytical recommendations as lynchpin for biological
Preliminary analytical reviews are performed to obtain an understanding of the business and its environment (eg financial performance relative to prior years and relevant industry and comparison groups), to help assess the risk of material misstatement in order to determine the nature, timing and extent of audit procedures, ie to help the
Next-generation sequencing (NGS) methods for cancer testing have been rapidly adopted by clinical laboratories. To establish analytical validation best practice guidelines for NGS gene panel testing of somatic variants, a working group was convened by the Association of Molecular Pathology with liaison representation from the College of American Pathologists. These joint consensus
Jan 1, 2020 · 6.2. Method transfer process. The method transfer process includes a series of steps starting with the planning and ending with a report stating that the receiving site is qualified to generate reportable results. The steps are shown in Fig. 6.1 and discussed in additional detail in the following sections.
May 6, 2019 · laboratory materials (balances, pens, computers) are not handled that will cause contamination, and that gloves are not used simply to keep hands clean! 3 Balance and Weighing Operations Analytical balances are high precision instruments and should be operated carefully. Excessive shock can damage a balanceAvoid shock loading the balance. .
Feb 5, 2017 · This study highlights the possibility of vial composition as a potential factor that impacts solution stability. Here we describe a case where the type of HPLC vial used results in an interesting phosphorous pseudorotation driven by the mild alkalinity of glass.
Feb 1, 2021 · Digital transformation refers to the unprecedented disruptions in society, industry, and organizations stimulated by advances in digital technologies such as artificial intelligence, big data analytics, cloud computing, and the Internet of Things (IoT). Presently, there is a lack of studies to map digital transformation in the environmental sustainability domain. This paper identifies the
Jun 18, 2021 · A matrix of different cell numbers is generated to find the most accurate and precise range. High-density cultures also can cause cells to detach from the plate wells; attachment factors can be added to help mitigate that effect. Plate-edge effects also can contribute to variability of cell-based potency assays.
Aug 14, 2023 · Analytical thinking is when you observe, research and develop critical insights from data or other information. When you use analytical thinking, you gain knowledge, solutions or ideas related to a problem or topic. There are several steps involved in analytical thinking: Identifying a topic, problem or issue.
This application note demonstrate that the use of an inappropriate vial can cause analyte adsorption or degradation, potentially leading to out of specification (OOS) results also describes how the type of glass vial selected can impact sample stability, demonstrated for lactone-containing analytes.